The Role of Triptans and Ditans in Acute Care
While CGRP drugs are the latest innovation, Triptans remain a foundational tool for stopping an attack already in progress. Triptans work by stimulating serotonin receptors ($5-HT_{1B/1D}$), which narrows swollen blood vessels and inhibits the release of pain-signaling chemicals.
For patients who do not respond to Triptans or who have heart conditions, 2026 medicine utilizes Ditans (specifically Lasmiditan). Unlike Triptans, Ditans target the $5-HT_{1F}$ receptor, which provides the same pain-relieving effect without causing "vasoconstriction" (the narrowing of blood vessels). This allows for effective acute treatment across a broader and more diverse patient population.
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